Some of you know already that specific B vitamins (B6, B12 and folate) are involved in the metabolism of homocysteine and that deficiency in these vital vitamins leads to atherosclerosis and cardiovascular disease. We rectified the misunderstanding about cholesterol causing the above conditions and showed how important biological molecule it is; at the end of the day it is not the causing agent of heart disease but a healing substance the body needs dearly. The blessings with B vitamins do not end with atherosclerosis though. Surely it shows how critical these vitamins are for the body but this is just one aspect of the multi functionality of the three angels. Many debilitating syndromes have been associated with deficiencies in B6, B12 and folate; more than you can imagine and completely varied. This is because they are involved in a group of omnipresent and super essential biochemical reactions that are known collectively as methylation process. Our 3 B vitamins act as co-factors in these reactions; in their absence the system does not work efficiently or not at all, depends on the level of deficiency we are talking about.
But what is methylation anyway? Without going into much technical detail I will give a simplified explanation. When a molecule is methylated, this means that a methyl group is added to it; a methyl group is a tiny extra molecule itself, imagine it a small tail that it is attached to a ball (the bigger molecule) when methylation occurs. The new chemical structure gives new properties to our big molecule which is now methylated. Usually methylation results in activating the original molecule. So, if we have a big molecule A for example and it is totally inactive by itself, then a little methyl group will transform it into its active version. Methylated A is now ready to fulfill its biochemical destiny in our body. When its mission is over, the methyl group will be removed from the molecule A and it will return into its inactive state until its services are needed again.
All these reactions (i.e. adding a methyl group to a molecule or removing it) happen in the human body with the help of enzymes, so in order for all the methylation to take place in time the enzymes must be fully functional and ready to perform their task. This is where the B vitamins come; they help the enzymes stay functional. The good thing with enzymes is that they only help the reactions happen, they do not really get involved in the reaction itself, so their quantities are not diminished or altered in any way; in fact they are regenerated after every cycle. The only thing they need is their helpers, the B vitamins, to keep them fit and ready to facilitate another cycle of biochemical reactions.
Well, this is the mystery of methylation, it doesn’t sound that exotic when you understand what it really isJ. It is very simple indeed; don’t let peculiar chemistry names confuse you. The juice of the methylation is that this simple reaction has been found to activate all sorts of very important molecules in the human body. In fact methylation has been found to regulate gene expression, DNA repair, detoxification (remember the detoxification of homocysteine for atherosclerosis???), regulation of protein function, hormone release and so many more; the list is very long… People of all ages and backgrounds need to have their methylation system in prime condition; it is fundamental for our biology. The only way to ensure that is by having your B6, B12 and folate vitamins storage super charged constantly. Research in China has shown that expectant mothers that did not include enough B vitamins in their diets (especially during the first trimester of the pregnancy) gave particularly often birth to babies with a birth defect called spina bifida or myelomeningocele. This can only prove to you how important B vitamins are and how essential biochemical systems in the body will consistently fail if these vitamins are not present in the required quantities.
As this is the first part of this topic I will close this post by insisting on the fact that our diet plays a massive role in the shape, health levels and fitness of our bodies. Food is powerful information for your cells and DNA , not just calories. Even in cases with people being genetically predisposed to certain conditions, diet will be the determining factor of whether the condition will manifest or not. B vitamins are just an example of just how basic these processes are.








